New insights into risk factors for transplant-associated thrombotic microangiopathy in pediatric HSCT
نویسندگان
چکیده
منابع مشابه
Transplant-Associated Thrombotic Microangiopathy in Childhood
Vascular endothelium is damaged by toxic agents during the preparation regimen for stem cell transplantation. Microthrombi develop in small arterioles and capillaries and cause partial obstruction. Erithrocytes are subjected to mechanical trauma, and as a result, to hemolysis and fragmentation. Patients have clinical symptoms similar to thrombotic thrombocytopenic purpura (TTP) and Hemolytic Ur...
متن کاملDiagnostic and risk criteria for HSCT-associated thrombotic microangiopathy: a study in children and young adults.
Transplant-associated thrombotic microangiopathy (TMA) leads to generalized endothelial dysfunction that can progress to multiorgan injury, and severe cases are associated with poor outcomes after hematopoietic stem cell transplantation (HSCT). Identifying patients at highest risk for severe disease is challenging. We prospectively evaluated 100 consecutive HSCT recipients to determine the inci...
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Transplant-associated thrombotic microangiopathy (TA-TMA) occurs frequently after hematopoietic stem cell transplantation (HSCT) and can lead to significant morbidity and mortality. There are no data addressing individual susceptibility to TA-TMA. We performed a hypothesis-driven analysis of 17 candidate genes known to play a role in complement activation as part of a prospective study of TMA i...
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Thrombotic microangiopathy (TMA) is a known complication of HIV infection. Endothelial cell injury appears to be the primary event causing platelet activation and deposition in the microvasculature. Direct cytopathic roles of HIV as well as other factors such as malignancy, drugs, and infectious agents have been implicated in the pathogenesis of HIV-TMA. Although the the majority of patients pr...
متن کاملPregnancy Associated Thrombotic Microangiopathy
The thrombotic microangiopathies (TMA) are a group of common microvascular occlusive disorders characterized by thrombocytopenia, microangiopathic hemolysis and multiorgan dysfunction. The pathological features are vascular damage manifested by arteriolar and capillary thrombosis with characteristic abnormalities in the endothelium and vessel wall. Pregnancy associated TMA is a life threatening...
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ژورنال
عنوان ژورنال: Blood Advances
سال: 2020
ISSN: 2473-9529,2473-9537
DOI: 10.1182/bloodadvances.2019001315